Coenzyme Q10 supplementation for the primary prevention of cardiovascular diseases: A structured literature review.
Item
- Title
- Coenzyme Q10 supplementation for the primary prevention of cardiovascular diseases: A structured literature review.
- Author(s)
- Chivallier, V
- Abstract
- Background Cardiovascular diseases (CVDs) are the number one cause of death and disability worldwide. The severity of heart failure correlates with the severity of coenzyme Q10 (CoQ10) deficiency. CoQ10 is an antioxidant that is naturally synthesised by the body and is also a non-prescription nutritional supplement. Objective The objective was to review up to date research regarding the efficacy of CoQ10 supplementation to prevent CVD or CVD risk factors. Methodological quality of studies was compared with the Cochrane review performed in 2014 into Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease. Design A structured literature review of randomised controlled trials (RCT) published between 2014-2019. Methods A search of the online databases ScienceDirect, PubMed, Mendeley, Google Scholar and Cochrane Library was performed in November 2019. Results were screened according to inclusion/exclusion criteria. Study data from the selected studies was extracted, and methodological quality was assessed using the Cochrane Collaboration’s tool for assessing risk of bias and the Delphi List. Results 16 eligible studies were identified and reviewed: 6 of the included studies were at high risk of bias, 1 study had an unclear risk of bias and 9 studies were judged with having a low risk of bias. The mean Delphi List score was 6.06±1.94. 15 studies found statistically significant reductions in one or more outcome measures. Discussion Interpretation of findings were limited by heterogeneity of participants, outcome measures and length of intervention. Only one study evaluated the incidence of major adverse cardiovascular events (MACE). Other studies looked at CVD risk factors however the studies were performed on a small scale thus they are lacking external validity and results can be considered inconclusive. Compared to the landmark study, the number of available evidence has increased as well as methodological quality. Conclusion CoQ10 supplementation is not supported by the current evidence in patients with CVD. Further studies are needed to determine the benefit of CoQ10 in patients suffering with CVD as well as to show the beneficial effect of CoQ10 in a healthy population in preventing occurrence of CVD before including it in guideline-directed medical therapy.
- presented at
- European School of Osteopathy
- Date Accepted
- 2020
- Date Submitted
- 28.10.2020 18:08:18
- Type
- osteo_thesis
- Language
- English
- Submitted by:
- 62
- Pub-Identifier
- 16652
- Inst-Identifier
- 1229
- Keywords
- Coenzyme Q10, Cardiovascular disease, Heart failure, Prevention
- Recommended
- 0
- Item sets
- Thesis
Chivallier, V, “Coenzyme Q10 supplementation for the primary prevention of cardiovascular diseases: A structured literature review.”, Osteopathic Research Web, accessed April 23, 2025, https://library.wso.at/s/orw/item/203